Search results for " LABA"

Why use long acting bronchodilators in chronic obstructive lung diseases? An extensive review on formoterol and salmeterol

2015

Abstract Long-acting β 2 -adrenoceptor agonists, formoterol and salmeterol, represent a milestone in the treatments of chronic obstructive lung diseases. Although no specific indications concerning the choice of one molecule rather than another are provided by asthma and COPD guidelines, they present different pharmacological properties resulting in distinct clinical employment possibilities. In particular, salmeterol has a low intrinsic efficacy working as a partial receptor agonist, while formoterol is a full agonist with high intrinsic efficacy. From a clinical perspective, in the presence of low β 2 -adrenoceptors availability, like in inflamed airways, a full agonist can maintain its b…

Limonium cedrorumsp. nov. (Plumbaginaceae) from Lebanon

2012

Limonium cedrorum Domina & Ramondo, a new species belonging to the L. palmare aggr., is described and illustrated from the inland near Becharre (Lebanon). Its relationships with morphologically close taxa are discussed. Limonium cedrorum differs from L. sieberi and L. postii mainly by looser inflorescences and larger flowers. It differs from L. galilaeum by longer outer bract and longer scale below the first inflorescence branch, few sterile branches, thicker base of the inflorescence and denser spikes, and from L. graecum by the shape of the infl orescence, longer basal internodes and the shape of the calyx.

Regular versus as-needed budesonide and formoterol combination treatment for moderate asthma: A non-inferiority, randomised, double-blind clinical tr…

2015

Summary Background Treatment guidelines for patients with moderate persistent asthma recommend regular therapy with a combination of an inhaled corticosteroid and a longacting β 2 agonist plus as-needed rapid-acting bronchodilators. We investigated whether symptom-driven budesonide and formoterol combination therapy administered as needed would be as effective as regular treatment with this combination plus as-needed symptom-driven terbutaline for patients with moderate asthma. Methods In this non-inferiority randomised clinical trial, we recruited adult patients (18–65 years of age) with stable moderate persistent asthma, according to 2006 Global Initiative for Asthma guidelines. Patients …

LABA/LAMA fixed-dose combinations in patients with COPD: A systematic review

2018

Paola Rogliani,1 Luigino Calzetta,1 Fulvio Braido,2 Mario Cazzola,1 Enrico Clini,3 Girolamo Pelaia,4 Andrea Rossi,5 Nicola Scichilone,6 Fabiano Di Marco7 1Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy; 2Department of Internal Medicine, IRCCS San Martino Genoa University Hospital, Genoa, Italy; 3Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy; 4Department of Medical and Surgical Sciences, Section of Respiratory Diseases, Magna Græcia University, Catanzaro, Italy; 5Pulmonary Unit, University of Verona, Verona, Italy; 6Department of Internal Medicine, University of Palermo, Palermo, Italy; 7…

Bībeles intertekstualitāte Migela de Unamuno romānā “Svētais Manuēls Labais Moceklis”

2018

Šis darbs ir veltīts Migeļa de Unamuno (Miguel de Unamuno) Bībeles intertekstuālu atsauču (tiešu, netiešu) izpētei Migeļa de Unamuno (Miguel de Unamuno) romānā: “Svētais Manuēls Labais moceklis” Pētījumā ir četras nodaļas, kas veido divas daļas: pirmā teorētiskā, kas sastāv no trijām pirmajām nodaļām un definē intertekstualitātes konceptu, parāda Unamuno dzīvi un darbu, īpaši romānu "Svētais Manuēls Labais moceklis". Otrā ir praktiskā daļa, kas sastāv no ceturtās nodaļas, tās mērķis ir atklāt un klasificēt bībliskās intertekstualitātes romānā. Galvenā uzmanība teorētiskajā daļā tiks pievērsta Džulijas Kristeva (Julia Kristeva) un Žerarda Ženeta (Gerard Genette) pētījumiem par to, kā viņi in…

La Corona d'Aragó en l'epistolari entre Jerónimo Borao i Víctor Balaguer (1848-1878)

2016

L’estudi analitza les vuitanta-una cartes —conservades a la Biblio- teca Museu Víctor Balaguer i en la seua major part inèdites— que el dra- maturg i polític Jerónimo Borao envià, entre els anys 1848 i 1878, al polític i intel·lectual català Víctor Balaguer. D’aquesta manera, s’hi assenyala l’in- terés de Borao a descobrir i difondre la història de la Corona d’Aragó, i també les relacions i els contactes que, quasi sempre a través de Balaguer, establí amb escriptors com ara el català Lluís Roca i el valencià Jacint La- baila. Finalment, s’evidencia com, a diferència dels seus conterranis, que buscaren relacionar-se amb els cercles madrilenys, l’escriptor romàntic ara- gon…

Gibt es Vorteile der ICS/LABA-Fixkombination hinsichtlich patientenrelevanter Parameter bei Asthma?

2009

Indacaterol/glycopyrronium/mometasone fixed dose combination for uncontrolled asthma

2021

INTRODUCTION Asthma symptoms can be relieved through a maintenance treatment combining long-acting β2-agonist and inhaled corticosteroids (LABA/ICS). However, for patients with inadequately controlled asthma, the LABA/ICS combination might not be sufficient. Under these conditions, clinical guidelines recommend the administration of inhaled long-acting muscarinic antagonists (LAMA) as an add-on therapy to LABA/ICS to better control asthma and improve lung function. For nearly two decades, the only LAMA to be approved on the market has been tiotropium. AREAS COVERED We reviewed recent clinical studies evaluating the safety and efficacy of LABA/LAMA/ICS fixed dose combinations by searching Pu…

Beliefs and preferences regarding biological treatments for severe asthma

2020

Background: Severe asthma is a serious condition with a significant burden on patients' morbidity, mortality, and quality of life. Some biological therapies targeting the IgE and interleukin-5 (IL5) mediated pathways are now available. Due to the lack of direct comparison studies, the choice of which medication to use varies. We aimed to explore the beliefs and practices in the use of biological therapies in severe asthma, hypothesizing that differences will occur depending on the prescribers’ specialty and experience. Methods: We conducted an online survey composed of 35 questions in English. The survey was circulated via the INterasma Scientific Network (INESNET) platform as well as throu…

Effects of a structured educational intervention in moderate-to-severe elderly asthmatic subjects.

2019

Background: Adherence to inhaled drugs is linked to patients’ satisfaction with their device, and an incorrect use can negatively affect the outcomes of asthma treatment. We speculated that this is particularly true in elderly asthmatic subjects. Aim: We performed a national pre-post interventional multicentre study, enrolling moderate-to-severe asthmatic subjects aged ≥65 ​years treated with fixed inhaled combination drugs by dry powder inhaler (DPI) or pressurized metered dose inhaler (pMDI). Adherence and critical errors were evaluated by means of validated questionnaires at first visit (V1) and after 3–6 months (V2). At V1, subjects underwent intensive training on the correct use of the…